Epimerization-free N to C solid-phase peptide synthesis

A method of synthesizing a peptide, wherein the method comprises preparing a first amino acid for synthesis, coupling an amino group of a second amino acid to the carboxyl group of the first amino acid to obtain a peptide, and optionally elongating the peptide by coupling one or more amino acids sequentially to a C-terminus of the peptide, wherein the amino acids used in the method are derivatized amino acids comprising a diamino-aryl group, and wherein the method proceeds without detectable epimerization of the second or sequentially coupled amino acid at the carboxyl terminus of the peptide.