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US 11,427,536 B2Granted
Photocatalyst-free, light-induced carbon-sulfur cross-coupling methods
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsGarret Miyake, Bin Liu, Chern-Hooi Lim
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Abstract
In one aspect, the invention provides a method of promoting a carbon-sulfur bond forming reaction. In certain embodiments, the reaction comprises cross-coupling of a(n) (hetero)aryl halide with a thiol to form the carbon-sulfur bond, wherein the method is promoted by light irradiation in the absence of a photocatalyst. In other embodiments, the cross-coupling reaction can be promoted through visible light irradiation, including sunlight.
Claims13
A method of generating an aryl or heteroaryl thioether, the method comprising:
- irradiating a system comprising an aryl or heteroaryl halide, a thiol, dimethyl sulfoxide (DMSO) or dimethyl acetamide (DMA), and at least one base with electromagnetic radiation, and
- forming a carbon-sulfur bond between the aryl or heteroaryl halide and the thiol to provide the aryl or heteroaryl thioether,
- wherein the system is free of transition metal and organic photocatalyst.
Dependencies are inferred from the claim text.