Compositions and methods for promoting hematopoietic stem cell regeneration
AssigneeDuke University
InventorLuigi Racioppi
Life of this patent
Estimating the term…
Abstract
Described is a method for promoting regeneration of hematopoietic stem and progenitor cells in a subject in need thereof. The method comprises administering to the subject a composition comprising a Ca2+/calmodulin (CaM)-dependent protein kinase kinase 2 (CaMKK2) inhibitor. The CaMKK2 inhibitor may be a small molecule inhibitor, such as 7H-benzimidazo(2,1-a)benz(de)isoquinoline-7-one-3-carboxylic acid (STO-609).
Claims10
A method of promoting regeneration of hematopoietic stem and progenitor cells (HSPCs) in a subject in need thereof, the method comprising administering to the subject an effective amount of a composition comprising a CaMKK2 inhibitor;
- wherein the CaMKK2 inhibitor is 7H-benzimidazo(2,1-a)benz(de)isoquinoline-7-one-3 carboxylic acid (STO-609);
- wherein the composition is administered systemically to the subject in a dose of 1 mg/kg to 30 mg/kg;
- wherein the subject has a bone marrow injury;
- and,
- wherein the composition is administered to the subject for less than 5 days following the bone marrow injury in the subject.
Dependencies are inferred from the claim text.