Immunomodulator compounds
AssigneeChemoCentryx, Inc.
InventorsChristopher Lange, Viengkham Malathong, Darren J. McMurtrie, Sreenivas Punna, Rajinder Singh, Ju Yang, Penglie Zhang
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Abstract
Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (II): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Claims6
A method of inhibiting growth, proliferation, or metastasis of cancer cells in a subject in need thereof, wherein the cancer cells are selected from the group consisting of colorectal cancer, mesothelioma;
- breast cancer, colorectal cancer, carcinoma of the endometrium, cancer of the esophagus, small cell lung cancer, renal cell carcinoma, Merkel cell carcinoma, hepatocellular carcinoma, primary mediastinal large B cell lymphoma;
- carcinoma of the cervix, gastric cancer, cancer of the bladder, classical Hodgkin's lymphoma, head and neck squamous cell carcinoma, and non-small cell lung cancer, comprising administering to the subject a therapeutically effective amount of a compound selected from the group consisting of
Dependencies are inferred from the claim text.