Back to results
US 11,421,249 B2Granted
Recombinant HVT vectors expressing multiple antigens of avian pathogens and uses thereof
AssigneeBoehringer Ingelheim Animal Health USA Inc.
InventorsMichel Bublot, Teshome Mebatsion, Joyce Pritchard, Perry Linz, Aemro Kassa
Life of this patent
Estimating the term…
Abstract
The present invention provides recombinant herpesvirus of turkeys (HVT) vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant HVT vectors and polyvalent vaccines comprising the recombinant HVT vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant HVT vectors.
Claims16
A recombinant herpesvirus of turkeys (HVT) vector comprising:
- a first heterologous polynucleotide encoding a first avian pathogen antigen;
- and
- a second heterologous polynucleotide encoding a second avian pathogen antigen,
- wherein the first avian pathogen is an Infectious Laryngotracheitis Virus (ILTV) glycoprotein D (gD) antigen having at least 80% sequence identity to SEQ ID NO:
- 17 or the first heterologous polynucleotide comprises a nucleotide sequence encoding an ILTV gD antigen that has at least 70% sequence identity to SEQ ID NO:
- 16,
- and wherein the second avian pathogen is an Infectious Bursal Disease Virus (IBDV) VP2 antigen or a Newcastle Disease Virus F (NDV-F) antigen.
4 more elements
Dependencies are inferred from the claim text.