System based on a new nitrile hydratase for highly efficient catalytic hydration reaction of aliphatic dinitriles
AssigneeDalian University of Technology
InventorsChanghai Liang, Li Wang, Shengxian Liu, Tongyi Dou, Changhao Cui
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Abstract
The invention belongs to the technical field of green chemistry, and provides a novel system based on a new nitrile hydratase for highly efficient catalytic conversion of aliphatic dinitriles. The invention discloses a new application of nitrile hydratase using Rhodococcus erythropolis CCM 2595 in catalyzing aliphatic dinitrile. In particular, the enzyme can regioselectivity catalyze the formation of 5-cyanopyramides from adiponitrile with high reaction rate under mild reaction conditions, which provides a new method for the industrial production of 5-cyanopyramides.
Claims3
A novel system based on a new nitrile hydratase for highly efficient catalytic hydration reaction of aliphatic dinitriles, wherein the concentration of a recombinant bacteria with nitrile hydratase derived from a Rhodococcus erythropohs CCM2595 is 1-3 g/L, the concentration of aliphatic dinitriles is 20-50 mM/L, and conversion system comprises phosphate buffer saline solution with pH 7-8.
Dependencies are inferred from the claim text.