Rebamipide prodrugs, preparation method and use thereof

A compound, selected from among a compound represented by the following Chemical Formula 1, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof:

• wherein,
• X is an oxygen atom, a nitrogen atom, or a sulfur atom;
• and
• Y is a radical selected from the group consisting of C1-C6 alkyl substituted with at least one substituent selected from the group consisting of with fluoro, chloro, bromo, oxo, nitro, and cyano, C1-C6 haloalkyl, (C1-C3 alkyloxy)C1-C6 alkyl, (C2-C6 alkenyloxy)C1-C6 alkyl, (C1-C6 alkylsufanyl)C1-C6 alkyl, (arylsufanyl)C1-C6 alkyl, (arylsulfonyl)C1-C6 alkyl, (C1-C6 alkylamino)C1-C6 alkyl, [(C1-C3 alkyl)(aryl)amino]C1-C6 alkyl, {[(C1-C3 alkyl)(aryl)C1-C3 alkyl]amino}C1-C6 alkyl, [(C1-C3 alkyl)(heteroaryl)amino]C1-C6 alkyl, (arylcarbonylamino)C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C2-C6 oxoalkyl, C3-C8 cycloalkyl, (C3-C8 cycloalkyl)C1-C6 alkyl, (C3-C8 cycloalkenyl)C1-C6 alkyl, (C3-C8 heterocycloalkyl)C1-C6 alkyl, [(C1-C3 alkyl)C3-C8 heterocycloalkyl]C1-C6 alkyl, {[(aryl)C1-C3 alkyl]C3-C8 heterocycloalkyl}C1-C6 alkyl, [(C1-C6 alkyloxycarbonyl)C3-C8 heterocycloalkyl]C1-C6 alkyl, [(C1-C3 alkyloxycarbonyl)C3-C8 heterocycloalkyl]C1-C6 alkyl, (C3-C8 heterocycloalkyl)C1-C6 alkenyl, [(C1-C3 alkyl)C3-C8 heterocycloalkenyl]C1-C6 alkyl, (aryl)C1-C6 alkyl, [(C1-C3 alkyl)aryl]C1-C6 alkyl, [(C1-C3 alkyloxy)aryl]C1-C6 alkyl, [(aryloxy)aryl]C1-C6 alkyl, [(C1-C3 alkylsufanyl)aryl]C1-C6 alkyl, [(C1-C3 alkyloxycarbonyl)aryl]C1-C6 alkyl, [(aryloxycarbonyl)aryl]C1-C6 alkyl, (aryl)C3-C6 alkenyl, (heteroaryl)C1-C6 alkyl, [(alkyloxycarbonyl)heteroaryl]C1-C6 alkyl, [(C1-C3 alkyl)C3-C8 heteroaryl]C1-C6 alkyl, [(C3-C8 cycloalkyl)heteroaryl]C1-C6 alkyl, [(aryl)heteroaryl]C1-C6 alkyl, [(C1-C3 alkyl)heteroaryl]C1-C6 alkyl, {[(aryl)C1-C3 alkyl]heteroaryl}C1-C6 alkyl, (C1-C6 alkyloxycarbonyl)C1-C6 alkyl, [(C3-C8 heterocycloalkyl)C1-C6 alkyloxycarbonyl]C1-C6 alkyl, (C3-C8 heterocycloalkylcarbonyl)C1-C6 alkyl, [(C1-C3 alkyl)C3-C8 heterocycloalkylcarbonyl]C1-C6 alkyl, [(C1-C3 alkyl)C3-C8 heterocycloalkylcarbonyl]C1-C6 alkyl, [(C3-C8 cycloalkyl)oxycarbonyloxy]C1-C6 alkyl, [(C3-C8 heterocycloalkyl)oxycarbonyloxy]C1-C6 alkyl, (ureido)C1-C6 alkyl, (arylureido)C1-C6 alkyl, [(aryl)(C1-C3 alkylureido]C1-C6 alkyl, (C1-C6 alkylaminocarbonyl)C1-C6 alkyl, [(C3-C8 heterocycloalkyl)aminocarbonyl]C1-C6 alkyl, {[(C1-C3 alkyl)C3-C8 heterocycloalkyl]aminocarbonyl}C1-C6 alkyl, [(C1-C3 alkyl)(C1-C3 alkyloxy)aminocarbonyl]C1-C6 alkyl, and (oxoC3-C8 heterocycloalkyl)C1-C6 alkyl,
• with a proviso that the C2-C6 alkenyl radical, the C2-C6 alkynyl radical, the C2-C6 oxoalkyl radical, the C3-C8 cycloalkyl radical, the C3-C8 cycloalkenyl radical, the C3-C8 heterocycloalkenyl radical, the aryl radical or the heteroaryl radical is optionally substituted with at least one substituent selected from the group consisting of C1-C3 alkyl, fluoro, chloro, bromo, hydroxy, oxo, nitro, and cyano.