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US 11,420,927 B2Granted
Process for the manufacture of alkylfluoroacrylate
AssigneePatheon Austria GmbH & Co KG
InventorsPeter Kapitan, Alexander Sajtos
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Abstract
The invention relates to a process for the manufacture of an alkylfluoroacrylate starting from alkylfluoroacetate and an oxalic acid ester, wherein an alkane liquid under the reaction conditions is applied as the solvent in one of the reaction steps.
Claims10
A process for the manufacture of a methylfluoroacrylate, comprising the following steps:
- A. a methylfluoroacetate with an ester of oxalic acid is reacted in the presence of a base and a suitable solvent in a crossed Claisen condensation reaction resulting in a Claisen salt;
- B. the Claisen salt obtained in step A is optionally filtered off and washed with a suitable solvent;
- C. the Claisen salt obtained in step A or B is reacted with paraformaldehyde in a suitable solvent;
- D. the methylfluoroacrylate obtained in step C is isolated using a suitable solvent, wherein the methylfluoroacrylate isolated after distillation has a purity of at least 99.5 wt %, contains below 0.5 wt % methylfluoroacetate and below 2.0 wt % dimethyl carbonate;
- wherein the solvent in at least steps C and D and optionally in one of steps A or B is an alkane selected from a group consisting of pentane and hexane.
2 more elements
Dependencies are inferred from the claim text.