Hydroxylated tropolone inhibitors of nucleotidyl transferases in herpesvirus and Hepatitis B and uses therefor

A compound of the formula:

• wherein:
• R1 and R6 are each independently selected from hydrogen, acyl(C≤8), or substituted acyl(C≤8);
• R2 and R5 are each independently selected from hydrogen, hydroxy, alkyl(C≤8), substituted alkyl(C≤8), cycloalkyl(C≤12), substituted cycloalkyl(C≤12), aryl(C≤8), substituted aryl(C≤8), heteroaryl(C≤8), substituted heteroaryl(C≤8), alkoxy(C≤8), substituted alkoxy(C≤8), acyl(C≤8), or substituted acyl(C≤8);
• R3 is hydroxy, cycloalkyl(C≤12), substituted cycloalkyl(C≤12), aryl(C7-18), substituted aryl(C7-18), heteroaryl(C≤12), substituted heteroaryl(C≤12), or —C(O)Ra, wherein:
• Ra is alkenyl(C≤11), aryl(C≤18), aralkyl(C≤11), heteroaryl(C≤18), aryloxy(C≤18), or a substituted version of any of these groups;
• and
• R4 is hydroxy, alkyl(C≤12), substituted alkyl(C≤12), cycloalkyl(C≤12), substituted cycloalkyl(C≤12), aryl(C≤18), substituted aryl(C≤18), heteroaryl(C≤12), substituted heteroaryl(C≤12), or —C(O)Ra, wherein:
• Ra is alkyl(C≤18), cycloalkyl(C≤18), alkenyl(C≤11), aryl(C≤18), aralkyl(C≤11), heteroaryl(C≤18), aryloxy(C≤18), -alkanediyl(C≤6)-cycloalkyl(C≤12);
• or a substituted version of any of these groups;
• or
• R3 and R4 are taken together and are a group of the formula:
• —(CH2)mC(O)A(CH2)n—, wherein:
• A is O or NRb, wherein:
• Rb is hydrogen, alkyl(C≤6), or substituted alkyl(C≤6);
• and
• m and n are each independently selected from 0, 1, 2, or 3;
• provided that the compound is not a compound of the following structures:
• or a pharmaceutically acceptable salt or tautomer thereof.