Methods of treating neurological disorders

A method of treating a neurological disorder characterized by the presence of a dipeptide repeat protein in cerebrospinal fluid (CSF), the method comprising contacting the CSF of a subject in need thereof with an effective amount of a protease capable of removing the dipeptide repeat protein, wherein the dipeptide repeat protein comprises two or more repeats of a dipeptide amino acid sequence, wherein the neurological disorder is selected from the group consisting of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), wherein the protease is proteinase K and is immobilized to an agarose substrate.

A method of treating a neurological disorder characterized by the presence of a dipeptide repeat protein in cerebrospinal fluid (CSF), the method comprising contacting the CSF of a subject in need thereof with an effective amount of a protease capable of removing the dipeptide repeat protein, wherein the dipeptide repeat protein comprises two or more repeats of a dipeptide amino acid sequence, wherein the protease is immobilized at a concentration of 1-10 milligrams per milliliter of the protease, the neurological disorder is selected from the group consisting of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), wherein the protease is proteinase K and the protease has higher specificity and higher affinity to the dipeptide repeat protein compared to a plurality of other proteins occurring in the CSF.