Porphyromonas gingivalis immune modulators and uses thereof
AssigneeTrustees of Tufts College
InventorsCaroline Attaro Genco, George Papadopoulos
Life of this patent
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Abstract
A heat killed Porphyromonas gingivalis bacterium expressing a homogenous lipid A structure having a molecular negative mass ion of 1368, 1435/1449, or 1690/1768 is used as an immunomodulator. The immunomodulator may be used in combination with an antigen of interest to potentiate or restrain a host immune response toward the selected antigen.
Claims30
A pharmaceutical composition comprising
- a) a heat killed Porphyromonas gingivalis bacterium expressing a homogenous lipid A structure having a molecular negative mass ion of 1368, 1435/1449, or 1690/1768;
- and
- b) a pharmaceutically acceptable carrier.
An immunomodulatory agent comprising a heat killed Porphyromonas gingivalis bacterium expressing a homogenous lipid A structure having a molecular negative mass ion of 1368, 1435/1449, or 1690/1768.
A pharmaceutical composition comprising
- a) a purified P. gingivalis lipopolysaccharide (LPS) where a lipid portion of LPS has a molecular negative mass ion of 1368, wherein the P. gingivalis bacterium is heat killed;
- and
- b) a pharmaceutically acceptable carrier.
A method for stimulating an immune response in a subject comprising administering a composition comprising a heat killed Porphyromonas gingivalis bacterium expressing a homogenous lipid A structure having a molecular negative mass ion of 1368, 1435/1449, or 1690/1768 and an antigen, wherein the composition promotes an immune response to the antigen.
A method for suppressing an immune response in a subject comprising administering a composition comprising a heat killed Porphyromonas gingivalis bacterium expressing a homogenous lipid A structure having a molecular negative mass ion of 1368, 1435/1449, or 1690/1768 and an antigen, wherein the composition inhibits an immune response to the antigen.
A method stimulating an immune response against a tumor in a subject, comprising administering to the subject a composition comprising a heat killed Porphyromonas gingivalis bacterium expressing a homogenous lipid A structure having a molecular negative mass ion of 1368, 1435/1449, or 1690/1768 and a tumor antigen from the tumor, in an amount sufficient to elicit an immune response against the tumor in the subject.
A method for suppressing an immune response against a self-antigen in a subject suffering from an autoimmune disease, comprising administering to the subject a composition comprising a heat killed Porphyromonas gingivalis bacterium expressing a homogenous lipid A structure having a molecular negative mass ion of 1368, 1435/1449, or 1690/1768 and a self-antigen, in an amount sufficient to suppress the immune response against the self-antigen.
Dependencies are inferred from the claim text.