Rapid isolation of cyclotron-produced gallium-68
AssigneeMayo Foundation for Medical Education and Research
InventorsMukesh K. Pandey, Timothy R. DeGrado
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Abstract
Methods for rapid isolation of radionuclides (e.g., 68Ga) produced using a cyclotron and methods for recycling of the parent isotope (e.g., 68Zn) are disclosed. In one version of the method, a solution including a radionuclide (e.g., 68Ga) is created from a target including cations (e.g., 68Zn). The solution including the radionuclide is passed through a first column including a sorbent comprising a hydroxamate resin to adsorb the radionuclide on the sorbent, and the radionuclide is eluted off the sorbent. The cations (e.g., 68Zn) are recovered from a recovery solution that has passed through the first column by passing the recovery solution through a second column including a second sorbent comprising a cation exchange resin.
Claims20
A method for producing a solution including a radionuclide, the method comprising:
- (a) bombarding a target solution with protons to produce a solution including a radionuclide, wherein the radionuclide is 68Ga;
- (b) passing the solution including the radionuclide through a column including a sorbent to adsorb the radionuclide on the sorbent;
- and
- (c) eluting the radionuclide off the sorbent,
- wherein the sorbent comprises a hydroxamate resin, and
- wherein pH of the solution including the radionuclide before passing the solution including the radionuclide through the column is between 5 and 7.
A method for producing a solution including a radionuclide, the method comprising:
- (a) bombarding a solid target with protons to produce a solid radionuclide,
- wherein the radionuclide is 68Ga;
- (b) creating a solution including the radionuclide from the solid radionuclide;
- (c) passing the solution including the radionuclide through a column including a sorbent to adsorb the radionuclide on the sorbent;
- and
- (d) eluting the radionuclide off the sorbent,
- wherein the sorbent comprises a hydroxamate resin, and
- wherein pH of the solution including the radionuclide before passing the solution including the radionuclide through the column is between 5 and 7.
Dependencies are inferred from the claim text.