Rapid vapor condensate collection and analysis
AssigneeEssenlix Corporation
InventorsStephen Y. Chou, Wei Ding
Life of this patent
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Abstract
The present invention is related to the field of bio/chemical sensing, assays and applications. Particularly, the present invention is related to collecting a small amount of a vapor condensate sample (e.g. the exhaled breath condensate (EBC) from a subject of a volume as small as 10 fL (femto-Liter) in a single drop), preventing or significantly reducing an evaporation of the collected vapor condensate sample, analyzing the sample, analyzing the sample by mobile-phone, and performing such collection and analysis by a person without any professionals.
Claims40
A method for collecting vapor condensate (VC) sample, comprising:
- (a) obtaining a device comprising a collection plate and a cover plate, wherein:
- i. the plates are movable relative to each other, having an open configuration and a closed configuration;
- ii. one or both plates are flexible and collect a VC sample that contains or is suspected of containing an analyte;
- iii. each of the plates has, on its respective surface, a sample contact area for contacting the VC sample;
- iv. one or both of the plates comprise spacers that are fixed with a respective plate, wherein the spacers have a predetermined substantially uniform height and a predetermined inter-spacer distance and wherein at least one of the spacers is inside the sample contact area;
- (b) depositing the vapor condensate sample onto one or both pates of the device;
- and
- (c) placing the plates in a closed configuration within 120 seconds after the end of step (b) depositing;
- and
- wherein, in the open configuration, the two plates are completely or partially separated and the spacing between the plates is not regulated by the spacers;
- and
- wherein, in the closed configuration, at least a part of the VC sample is between the two plates and in contact with the two plates, having a highly uniform thickness that is regulated by the spacers and the two sample surfaces of the plates.
Dependencies are inferred from the claim text.