Osteochondral scaffold
AssigneeUCL Business PLC
InventorsChaozong Liu, Gordon Blunn
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Abstract
There is described a multiphasic osteochondral scaffold for osteochondral defect repair, the scaffold comprising a bone phase and a cartilage phase, wherein the bone phase comprises a support matrix and the cartilage phase comprises a polymeric matrix, and the scaffold comprises a non-porous layer between the bone phase and the cartilage phase. Also described is a multiphasic osteochondral scaffold for osteochondral defect repair, the scaffold comprising a bone phase and a cartilage phase, wherein the bone phase comprises a support matrix and the cartilage phase comprises a polymeric matrix, and wherein the support matrix is tapered so that the dimensions of the support matrix are less at the lower end of the support matrix than at the upper end of the support matrix.
Claims21
A multiphasic osteochondral scaffold for osteochondral defect repair, the scaffold comprising a bone phase and a cartilage phase, wherein the bone phase comprises a metallic support matrix and the cartilage phase comprises a polymeric matrix, and the scaffold comprises a non-porous layer between the bone phase and the cartilage phase, wherein the polymeric matrix partially overlaps with and is embedded in the support matrix, and wherein the non-porous layer is present in the region of overlap and acts to join the support matrix to the polymeric matrix,
- wherein, in use, the non-porous layer prevents synovial fluid from diffusing into the bone phase from the cartilage phase when subjected to dynamic compressive load, and
- wherein the non-porous layer is formed by at least partially melting one end of the polymeric matrix into the support matrix so that the melted polymeric matrix forms the non-porous layer in a portion of the support matrix.
Dependencies are inferred from the claim text.