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US 11,413,356 B2Granted
Methods and compositions for treating metabolic imbalance
AssigneeUniversity of Massachusetts
InventorsGuangping Gao, Dominic Gessler
Life of this patent
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Abstract
In some aspects, the disclosure relates to compositions and methods useful for the diagnosis and treatment of diseases associated with a metabolic imbalance in a subject (e.g., cancer). In some embodiments, the methods comprise administering to a subject an N-acetylaspartate (NAA)-depleting agent or an N-acetylaspartate (NAA)-increasing agent based upon the subject's metabolic profile.
Claims18
A method for treating a disease associated with a metabolic imbalance in a subject in need thereof, the method comprising:
- administering to the subject a recombinant adeno-associated virus (rAAV) comprising a nucleic acid molecule, wherein the nucleic acid molecule comprises the sequence according to SEQ ID NO:
- 1 encoding aspartoacylase (ASPA),
- wherein the disease is associated with a metabolic imbalance comprising a shift from beta-oxidation to glycolysis in the subject,
- wherein the disease is a cancer.
1 more element
Dependencies are inferred from the claim text.