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US 11,413,347 B2Granted
Vaccine composition and method of preventing porcine epidemic diarrhea virus infection in swine
AssigneeReber Genetics Co., Ltd.
InventorsChia-Jung Chang, Jen-Yu Chang, Cheng-Xin Yang
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Abstract
A vaccine composition includes a porcine epidemic diarrhea virus (PEDV) S1 spike protein having an amino acid sequence of SEQ ID NO: 1, and an inactivated porcine epidemic diarrhea virus (PEDV). The vaccine composition is used in a method of preventing PEDV infection in swine, whereby systemic Immunoglobulin G (IgG), Immunoglobulin A (IgA) and neutralizing antibody may be successfully induced by the vaccine composition, hence providing sufficient immune protection against PEDV.
Claims7
A vaccine composition, comprising:
- component (A):
- a modified porcine epidemic diarrhea virus (PEDV) S1 spike protein encoded with a nucleotide sequence consisting of SEQ ID NO:
- 3;
- component (B):
- an inactivated porcine epidemic diarrhea virus (PEDV) comprising the nucleotide sequence of SEQ ID NO:
- 4, wherein the component (A) and the component (B) are separate components;
- and
- mineral oil-based adjuvants.
5 more elements
Dependencies are inferred from the claim text.