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US 11,413,319 B2Granted
Microencapsulation of bacteriophages and related products
AssigneePhagelux (Canada) Inc.
InventorsNancy Tawil, Edwige Caroline Rebecca Arnold, Ramaz Katsarava, David Tugushi, Vakhtang Beridze
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Abstract
An encapsulated bacteriophage formulation and a method for encapsulating bacteriophages and bacteriophage-related products in polymeric microcapsules is provided. Some embodiments of the method of producing the encapsulated bacteriophages involves a water-in-oil-in-water double emulsion.
Claims29
A composition comprising:
- polymer microcapsules;
- and
- active bacteriophages encapsulated in the polymer microcapsules;
- wherein the polymer microcapsules include an amino-acid based polymer and the active bacteriophages are dispersed in the polymer microcapsules;
- wherein the amino-acid based polymer is a poly (ester amide urea) comprising the following two blocks with random distribution thereof
- wherein
- the ratio of l:m ranges from 0.05:0.95 to 0.95:0.05, l+m=1,
- R1 is chosen from C2-C12 alkylenes optionally interrupted by at least one oxygen, C3-C8 cycloalkylenes, C3-C10 cycloalkylalkylenes,
- R3 is C2-C12 alkylene,
- R2 and R4 are independently chosen from the side chains of L- and D- amino acids so that the carbon to which R2 or R4 is attached has L or D chirality.
7 more elements
Dependencies are inferred from the claim text.