Monolithic intravaginal rings comprising progesterone and methods of making and uses thereof

A method of manufacturing a monolithic intravaginal progesterone ring, comprising:

• (a) mixing progesterone, a polysiloxane elastomer composition, and a pharmaceutically acceptable hydrocarbon or glycerol esters of a fatty acid or pharmaceutically acceptable oil, to form a homogeneous mixture;
• (b) placing the homogeneous mixture into a mold;
• and
• (c) curing the homogeneous mixture in the mold to form a monolithic intravaginal progesterone ring comprising about 10% to about 30% by weight of the progesterone, about 60% to about 80% by weight of polysiloxane elastomer, and about 1% to about 8% by weight of the pharmaceutically acceptable hydrocarbon or glycerol esters of fatty acid or pharmaceutically acceptable oil, wherein the progesterone is homogeneously dispersed in the elastomer.