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US 11,413,274 B2Granted
Methods and compositions associated with the granulocyte colony-stimulating factor receptor
AssigneeLigand Pharmaceuticals Incorporated
InventorsLin Zhi, Keith Marschke, Virginia H. Grant, Steven L. Roach, Yixing Shen, Jason C. Pickens, Bijan Pedram, Cornelis Arjan van Oeveren, Lino J. Valdez, Andrew R. Hudson
Life of this patent
Estimating the term…
Abstract
Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor receptor (GCFR). Some embodiments include use of compounds to treat certain disorders, such as hematopoietic or neurological disorders.
Claims8
A compound of Formula (IIb) having the following structure:
- a tautomer thereof, or a pharmaceutically acceptable salt thereof, wherein
- R3 is selected from hydrogen, an optionally substituted C1-C6 alkyl, an optionally substituted C3-C8 cycloalkyl, an optionally substituted C1-C6 heterocycle, an optionally substituted aryl, and an optionally substituted heteroaryl;
- R4 is selected from an optionally substituted C1-C6 alkyl, an optionally substituted C3-C8 cycloalkyl, an optionally substituted C1-C6 heterocyclyl;
- and
- R9 is selected from hydrogen, an optionally substituted C1-C6 alkyl, an optionally substituted C3-C8 cycloalkyl, an optionally substituted C1-C6 heterocyclyl, an optionally substituted heteroaryl, an optionally substituted arylalkyl, and an optionally substituted heteroarylalkyl.
2 more elements
Dependencies are inferred from the claim text.