Hemostatic paste and methods of making thereof
AssigneesGuangzhou Bioseal Co., Ltd., Johnson & Johnson China Ltd., Ethicon, Inc.
InventorsDengmin Feng, Ling Teng, Yanhui Zhang, Guojun Ni, Yufu Li, Xiang Wan
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Abstract
The present invention is directed to a flowable hemostatic paste comprising a crosslinked carboxymethyl cellulose and at least one non-toxic dispersant. More specifically the present invention relates to a hemostatic paste containing citric acid cross-linked CMC, which is suspended or dispersed as a powder in a mixture of a first non-toxic glycerol-containing hygroscopic dispersant and a second non-toxic alcohol functionalized dispersant comprising propylene glycol or 1,3-butanediol.
Claims14
A flowable hemostatic paste comprising:
- A xerogel crosslinked milled polysaccharide dispersed within a substantially anhydrous blend of:
- i. A glycerol-containing dispersant, and
- ii. An alcohol-functionalized dispersant selected from the group consisting of propylene glycol and 1,3-Butanediol or mixtures thereof,
- wherein the paste has a moderate viscosity at rest and room temperature and provides a substantially homogenous dispersion of the crosslinked polysaccharide, and wherein:
- (i) said paste comprises a weight ratio of propylene glycol to glycerol of from about 1:0.5 to about 1:2;
- (ii) said paste further comprises an alkaline agent;
- and/or
- (iii) the weight ratio of cross-linked polysaccharide to glycerol-containing dispersant ranges from about 0.9 to about 1.25.
Dependencies are inferred from the claim text.