Composition and uses thereof
OwnerHilary McMahon, Regina O'Sullivan +1inventors
InventorsHilary McMahon, Regina O'Sullivan, Ana Herrero
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Abstract
The present invention relates to a composition for degrading prion material comprising a Thermitase. Such compositions may be formed in solution and are particularly suited to degrading prion material on medical equipment or in the environment due to the Thermitases mild pH range and activity at relatively low temperatures. The present invention also relates to novel proteases, methods for prion degradation, decontamination or disinfection and a kit of parts.
Claims17
A disinfectant composition for degrading a PrPsc prion or PrPsc prion material on medical equipment or in the environment, the disinfectant composition comprising a Thermitase and a buffer, wherein the Thermitase is present in an effective amount to degrade the PrPsc prion or PrPsc prion material to an undetectable level when measured according to a western blot analysis.
A protease having the amino acid sequence of:
- SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 4, or SEQ ID NO:
- 5.
A kit of parts for prion disinfection, comprising:
- a) a Thermitase having the amino acid sequence of:
- SEQ ID NO:
- 1 and/or SEQ ID NO:
- 4, or a sequence having 95% or more homology thereof;
- and
- b) a buffer solution having a pH in the range of 6 to 13.
Dependencies are inferred from the claim text.