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US 11,407,851 B2Granted
Chemically modified shape memory polymer embolic foams with increased X-ray visualization
AssigneeThe Texas A&M University System
InventorsLandon D. Nash, Kendal P. Ezell
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Abstract
An embodiment includes a system comprising: an iodine containing thermoset open-cell shape memory polymer (SMP) foam that is x-ray visible; wherein (a) the SMP foam is configured to expand from a compressed secondary state to an expanded primary state in response to thermal stimulus, (b) the SMP foam is a poly(urethane-urea-amide). Other embodiments are described herein.
Claims14
A system comprising:
- a radiopaque thermoset shape memory polymer (SMP) foam that is covalently bonded to iodine;
- wherein (a) the SMP foam is configured to expand from a compressed secondary state to an expanded primary state in response to thermal stimulus, (b) the SMP foam is a poly(urethane-urea-amide), (c) the iodine is included in 5-amino-2,4,6-triiodoisophthalic acid (ATIPA), and (d) the SMP foam does not include a tertiary amine.
A system comprising:
- an iodine containing thermoset open-cell shape memory polymer (SMP) foam that is x-ray visible;
- wherein (a) the SMP foam is configured to expand from a compressed secondary state to an expanded primary state in response to thermal stimulus, (b) the SMP foam is a poly(urethane-urea-amide), (c) the iodine is derived from 5-amino-2,4,6-triiodoisophthalic acid (ATIPA), and (d) the SMP foam does not include a tertiary amine.
A method comprising:
- providing 5-amino-2,4,6-triiodoisophthalic acid (ATIPA);
- providing at least one aliphatic monomer comprising at least one of (a)(i) multiple amine functional groups, (a)(ii) multiple alcohol functional groups, (a)(iii) multiple carboxylic acid functional groups, or (a)(iv) combinations thereof;
- providing a diisocyanate;
- mixing the ATIPA, the at least one aliphatic monomer, and the diisocyanate into a solution;
- forming a radiopaque thermoset open-cell shape memory polymer (SMP) foam from the solution;
- wherein the SMP foam:
- (a) includes iodine that is derived from the ATIPA, (b) is configured to expand from a compressed secondary state to an expanded primary state in response to thermal stimulus, (c) is a poly(urethane-urea-amide), and (d) does not include a tertiary amine.
4 more elements
Dependencies are inferred from the claim text.