Optically-active cyclopentenone derivatives
AssigneesTohoku University, Genesis Research Institute, Inc., Ouchi Shinko Chemical Industrial Co., Ltd.
InventorsHitoshi Kasai, Yoshitaka Koseki, Takaaki Kamishima, Shigenobu Aoyagi
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Abstract
The present invention provides: industrially desirable and novel optically-active cyclopentenone derivatives; and a novel industrial manufacturing method. The novel optically-active cyclopentenone derivatives and method for manufacturing the same are, respectively: an intermediate for industrially desirable and novel prostaglandin derivatives and the like; and a method for manufacturing the same. It is expected that the present invention will be commercialized and industrialized.
Claims5
A method for producing the compound of formula (3) or the compounds of formula (4), comprising reacting the compound of formula (2) with a carboxylic acid ester of an unsaturated alcohol in the presence of a hydrolase to give a mixture of the compounds of formula (3) and formula (4), wherein the mixture of the compounds of formula (3) and formula (4) is then separated to produce an optically-active compound of formula (3) or an optically active compound of formula (4), wherein R1 is tert-butyldimethylsilyl or triphenylmethyl and R2 is an acyl group
A compound represented by formula (I) or an optically-active form thereof,
- wherein,
- R1 is a tent-butyldimethylsilyl, and
- R2 is acetyl, propionyl, n-butyryl, iso-butyryl, n-valeryl or caproyl, and wherein the * represents an asymmetric carbon atom.
A compound represented by formula (I) or an optically-active form thereof,
- wherein,
- R1 is triphenylmethyl, and
- R2 is an acyl group, and
- wherein the * represents an asymmetric carbon atom.
Dependencies are inferred from the claim text.