Tissue substitute multilayer matrix and uses thereof
AssigneeNurami Medical Ltd.
InventorsNora Nseir Manassa, Amir Bahar
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Abstract
Compositions-of-matter comprising a matrix made of one or more, preferably two or more elastic layers and one or more viscoelastic layer are disclosed. The compositions-of-matter are characterized by high water-impermeability and optionally by self-recovery. Processes of preparing the compositions-of-matter and uses thereof as tissue substitutes or for repairing damaged tissues are also disclosed.
Claims16
An article-of-manufacture comprising a multi-layer, suturable and/or stapleable matrix, said matrix comprising at least one layer of an elastic polymeric material characterized by a recovery of at least 75%, at least one layer of a viscoelastic polymeric material,
- wherein said layer of a viscoelastic polymeric material is characterized by at least one of:
- a) a storage shear modulus (G′) in a range of from 0.01 to 10 MPa, at a temperature of 10° C. and frequency of 0.1 Hz;
- b) a loss shear modulus (G″) in a range of from 0.0001 to 2 MPa, at a temperature of 10° C. and frequency of 0.1 Hz;
- c) a glass transition temperature and/or melting point of said viscoelastic polymeric material which is at a temperature below 40° C.;
- and
- d) a loss tangent (G″/G′) at a temperature of 10° C. and frequency of 0.1 Hz which is in a range of from 0.02 to 1,
- and wherein said layer of an elastic polymeric material is characterized by at least one of:
- a) an elastic modulus in a range of from 1 kPa to 10 MPa, as determined in accordance with ASTM international standard D882-12;
- b) an elongation at failure in a range of at least 100%;
- and
- c) a glass transition temperature and/or melting point of said elastic polymeric material which is at a temperature above 40° C.
Dependencies are inferred from the claim text.