Co-crystals of Nurr1-LBD in complex with a cyclopentenone prostaglandin and modulators of Nurr1
AssigneeNanyang Technological University
InventorsHo Sup Yoon, Sreekanth Rajan, Hui Ting Toh, Xuewei Liu, Hui Yao
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Abstract
Co-crystals comprising the Nuclear receptor related 1 protein-ligand binding domain (Nurr1-LBD) and a cyclopentenone prostaglandin are provided. Also provided are methods of identifying or designing Nurr1-modulating ligands and compounds based on the crystal structures described herein as well as the applications of said ligands and compounds as Nurr1 modulators or medicaments.
Claims2
A co-crystal consisting of a Nuclear receptor related 1 protein-ligand binding domain (Nurr1-LDB) and a cyclopentenone prostaglandin, wherein the Nurr1-LBD has the amino acid sequence set forth in SEQ ID NO:1, the cyclopentenone prostaglandin is PGA1, and wherein the co-crystal is described by the atomic coordinates deposited at the Protein Data Bank (PDB) under accession number 5Y41.
A co-crystal consisting of a Nuclear receptor related 1 protein-ligand binding domain (Nurr1-LBD) and a cyclopentenone prostaglandin, wherein the Nurr1-LBD has the amino acid sequence set forth in SEQ ID NO:1, the cyclopentenone prostaglandin is PGA2, and wherein the co-crystal is described by the atomic coordinates deposited at the Protein Data Bank (PDB) under accession number 5YD6.
Dependencies are inferred from the claim text.