Anti-thrombogenic medical devices and methods
AssigneeCovidien LP
InventorsXiaodong Ma, Min-Shyan Sheu, Lincoln Eramo, John Wainwright, Junwei Li
Life of this patent
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Abstract
Methods for forming an expandable tubular body having a plurality of braided filaments including a first filament including platinum or platinum alloy and a second filament including cobalt-chromium alloy. The methods include applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament and applying a silane material on the second filament followed by a second phosphorylcholine material on the silane material on the second filament. The first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.
Claims19
A medical device, comprising:
- a braided vascular device comprising a plurality of braided filaments, wherein the braided vascular device is configured to be implanted in a blood vessel, wherein a flow-diverting section of the braided vascular device includes a sidewall formed by the plurality of braided filaments and having a plurality of pores sized to inhibit flow of blood through the sidewall into an aneurysm to a degree sufficient to lead to thrombosis and healing of the aneurysm when the braided vascular device is in an expanded state, and wherein at least some respective filaments of the plurality of braided filaments in the flow-diverting section comprise:
- a substrate comprising at least one of cobalt, cobalt alloy, chromium, chromium alloy, nickel, or nickel alloy;
- a silane material on the substrate;
- and
- a phosphorylcholine material on the silane material,
- wherein the phosphorylcholine material defines a thickness of less than 100 nanometers, and
- wherein the flow-diverting section of the braided vascular device exhibits at least one of:
- a time elapsed before onset of thrombin formation that is greater than about 1.5 times a time elapsed before onset of thrombin formation of a similar braided vascular device without the phosphorylcholine material,
- a time elapsed before peak thrombin formation that is less than about 0.8 times a time elapsed before peak thrombin formation of the similar braided vascular device without the phosphorylcholine material, or
- a peak thrombin concentration that is less than about 0.8 times a peak thrombin concentration of the similar braided vascular device without the phosphorylcholine material.
Dependencies are inferred from the claim text.