US 11,401,463 B2 · Luminescent particles based on rare earth elements and use thereof as a diagnostic agent

Abstract

The present invention concerns a luminescent particle comprising a nanoparticle of formula A1-xLnxVO4(1-y)(PO4)y (I) in which A is selected from yttrium (Y), gadolinium (Gd), lanthanum (La), and mixtures thereof; Ln is selected from europium (Eu), dysprosium (Dy), samarium (Sm), neodymium (Nd), erbium (Er), ytterbium (Yb), and mixtures thereof; 0<x<1; and 0≤y<1; characterized in that the nanoparticle on its surface has tetraalkylammonium cations in an amount such that said nanoparticle has a zeta potential, ζ, of less than or equal to −28 mV in an aqueous medium with a pH≥5, more particularly with a pH≥5.5, and with an ionic conductivity >100 μS·cm−1. It also concerns a method for preparing such luminescent particles, a colloidal suspension of these particles, and the use thereof as a diagnostic agent, and also a diagnostic kit comprising such luminescent particles.

Claims26

Dependent claims

A luminescent particle comprising a nanoparticle of formula:

A1-xLnxVO4(1-y)(PO4)y (I)
in which:
A is selected from yttrium (Y), gadolinium (Gd), lanthanum (La), and mixtures thereof;
Ln is selected from europium (Eu), dysprosium (Dy), samarium (Sm), neodymium (Nd), erbium (Er), ytterbium (Yb), and mixtures thereof;
0<x<1;
and
0≤y<1;
wherein the nanoparticle has, at the surface, tetraalkylammonium cations in an amount such that said nanoparticle has a zeta potential, ζ, of less than or equal to −28 mV in an aqueous medium with a pH≥5, and with an ionic conductivity of strictly less than 100 μS·cm−1.

5 more elements

A method for preparing luminescent particles comprising a nanoparticle of formula:

A1-xLnxVO4(1-y)(PO4)y (I)
in which:
A is selected from yttrium (Y), gadolinium (Gd), lanthanum (La), and mixtures thereof;
Ln is selected from europium (Eu), dysprosium (Dy), samarium (Sm), neodymium (Nd), erbium (Er), ytterbium (Yb), and mixtures thereof;
0<x<1;
and
0≤y<1;
by coprecipitation reaction, in aqueous medium, from precursors of said elements A and Ln, and in the presence of orthovanadate (VO43−) and optionally phosphate (PO43−) ions;
said reaction being performed in the presence of an effective amount of tetraalkylammonium cations such that said nanoparticle has a zeta potential, ζ, of less than or equal to −28 mV in an aqueous medium with a pH≥5, and with an ionic conductivity of strictly less than 100 μS·cm−1.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application

16/614,055Filed 18 May 2018

Priority

FR 175441618 May 2017

Published

US 2020/0172800 A14 Jun 2020

Granted

2 Aug 2022

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

C09K 11/025
Use of particular materials as binders, particle coatings or suspension media therefor: non-luminescent particle coatings or suspension media
A61K 33/02
Medicinal preparations containing inorganic active ingredients: ammonia; Compounds thereof
A61K 49/0065
Characterised by a special physical or galenical form, e.g. emulsions, microspheres: the luminescent/fluorescent agent having itself a special…
A61K 49/101
Organic compounds: the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals

Luminescent particles based on rare earth elements and use thereof as a diagnostic agent

Life of this patent

Luminescent particles based on rare earth elements and use thereof as a diagnostic agent

Life of this patent

Abstract

Claims26