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US 11,401,309 B2Granted
Protein M fusion proteins and uses
OwnerJay Dela Cruzinventor
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Abstract
Fusion proteins with immunoglobulin binding properties, their uses and related methods and compositions are disclosed. The fusion proteins are comprised of an antibody-binding fragment of protein M from Mycoplasma spp. conjugated to a receptor fragment. The receptor fragment is a protein fragment to which a pathogen, a toxin or a cancer cell can specifically bind. The fusion proteins can be used to neutralize or eradicate a wide group of pathogens, toxins or cancer cells.
Claims30
A conjugate comprising:
- a first polypeptide having a specific binding affinity for an immunoglobulin molecule, wherein the first polypeptide has at least 99% identity over its entire length to one of SEQ ID NOS:
- 1, 2, and 63-66;
- conjugated to
- a second polypeptide having a specific binding affinity for a pathogen, a toxin or a cancer cell.
1 more element
A fusion protein comprising:
- a first polypeptide having a specific binding affinity for an immunoglobulin molecule, wherein the first polypeptide has at least 99% identity over its entire length to one of SEQ ID NOS:
- 1, 2, and 63-66;
- genetically fused to
- a second polypeptide having a specific binding affinity for a pathogen, a toxin or a cancer cell.
1 more element
Dependencies are inferred from the claim text.