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US 11,401,298 B2Granted
Means and methods for site-specific functionalization of polypeptides
AssigneesLudwig-Maximilians-Universitat Munchen, Forschungsverbund Berlin E.V.
InventorsHeinrich Leonhardt, Jonas Helma, Dominik Schumacher, Christian Hackenberger
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Abstract
The present invention provides means and methods for equipping a polypeptide of interest at its C-terminus with a versatile adaptor amino acid that allows the functionalization of the polypeptide of interest.
Claims8
An antibody or fragment thereof having a length of more than 19 amino acids, wherein the antibody or fragment thereof comprises a recognition sequence for tubulin-tyrosinate ligase (TTL) at its C-terminus, wherein the recognition sequence comprises the amino acid sequence X4X3X2X1 (SEQ ID No:
- 11), wherein X4 is E, D, A, K, or P, X3 is G, S, A, V or F, X2 is E, D or C, and X1 is E, and wherein the antibody or fragment thereof further comprises tyrosine derivative 1 covalently bonded to said recognition sequence:
Dependencies are inferred from the claim text.