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US 11,401,245 B2Granted
Compositions for the treatment of pulmonary fibrosis
AssigneeVectus Biosystems Limited
InventorKaren Annette Duggan
Life of this patent
Estimating the term…
Abstract
The present invention relates to compounds and their use in the prophylactic and/or therapeutic treatment of pulmonary fibrosis and/or related conditions.
Claims6
A method of therapeutically treating pulmonary fibrosis, or a related condition in a subject with pulmonary fibrosis, the method comprising administering to the subject an effective amount of a compound of the formulae:
- or a pharmacologically acceptable salt, stereoisomer, diastereomer, enantiomer, racemate, hydrate and/or solvate thereof,
- wherein:
- A is selected from optionally substituted saturated, partly saturated or unsaturated 5- or 6-membered heterocyclyl;
- optionally substituted C1-6alkoxyl amine;
- optionally substituted C1-6alkyl amine;
- optionally substituted C0-6alkyl carboxylic acid;
- optionally substituted C1-6alkyl hydroxyl;
- optionally substituted saturated or unsaturated C0-6alkyl bicyclic heterocyclyl;
- and optionally substituted saturated or unsaturated C1-6alkoxyl bicyclic heterocyclyl;
- D is:
- T is independently selected from C1-6alkyl, halo, C0-6alkyl carboxylic acid, amino, hydroxy and C1-6alkoxy;
- m is 0, 1, 2, 3 or 4;
- and
- X is —OH or
- wherein m cannot be 0 when X is —OH.
12 more elements
A compound of the formula
- or a pharmacologically acceptable salt, stereoisomer, diastereomer, enantiomer, racemate, hydrate and/or solvate thereof.
Dependencies are inferred from the claim text.