Deuterated compounds and uses thereof
AssigneeOncotherics Ventures Limited
InventorsStefan Ogrodzinski, Paul Smith, Stephanie McKeown, Laurence Patterson, Rachel Jane Errington
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Abstract
An anthraquinone compound of formula I (such as the compounds of formulae II to X) and processes for making the same are provided. Pharmaceutical compositions for use in the treatment of cancer, optionally in combination with an agent capable of reducing the level of oxygenation of a tumour, are also provided. Additionally, an option for combination with chemotherapeutic and radiotherapeutic modalities to enhance overall tumour cell kill is provided. Methods for the detection of cellular hypoxia, both in vivo and in vitro, are additionally provided.
Claims41
A compound of Formula IV or VI:
- wherein Y are each independently selected from the group consisting of hydrogen, hydroxy, halogeno, amino, C1-4 alkoxy and C2-8 alkanoxy.
A method of detecting hypoxic cells in vitro or in vivo in a group of cells, the method comprising:
- exposing a compound of Formula VI:
- wherein Y are each independently selected from the group consisting of hydrogen, hydroxy, halogeno, amino, C1-4 alkoxy and C2-8 alkanoxy
- to the group of cells;
- analysing the cells for the presence of a corresponding reduced compound of Formula IV
- and determining the hypoxic cells based on the presence of the corresponding reduced compound.
Dependencies are inferred from the claim text.