Kit and method for detecting porous dental hydroxyapatite
AssigneeIncisive Technologies Pty Ltd
InventorsMichael James Hubbard, Jonathan Edward Mangum
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Abstract
The present invention relates to a kit and a probe for detecting porous dental hydroxyapatite that includes a protein capable of binding porous dental hydroxyapatite or a detector thereof. The invention also relates to a method for detecting a condition involving porous dental hydroxyapatite that includes detecting in or on a tooth or a sample of the tooth of a subject a protein bound to porous dental hydroxyapatite. The invention also relates to methods for detecting a hypomineralisation developmental dental defect or detecting intact and/or broken MIH enamel, and to a kit and method for removing a protein bound to porous dental hydroxyapatite.
Claims24
A method for detecting porous dental hydroxyapatite, the method comprising:
- (a) contacting a tooth of a subject with a probe comprising a protein covalently linked to a coloured reporter, wherein the protein is selected from the group consisting of Serum albumin;
- Complement C3 beta chain;
- Alpha-1-antitrypsin;
- Protein S100-A9;
- Lactotransferrin;
- Leukocyte elastase inhibitor;
- Antithrombin-III;
- Hemoglobin subunit alpha;
- Hemoglobin subunit beta;
- Hemoglobin subunit delta;
- Prolactin-inducible protein;
- Alpha amylase 1;
- Ig kappa chain V-III region SIE;
- Ig alpha-2 chain C region;
- Uncharacterized protein c6orf58;
- Serpin B3;
- and Amelogenin, wherein the protein specifically binds to porous dental hydroxyapatite;
- and
- (b) detecting the probe specifically bound to the porous dental hydroxyapatite, thereby locating the porous dental hydroxyapatite.
Dependencies are inferred from the claim text.