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US 11,396,668 B2Granted
Methods of producing nor-opioid and nal-opioid benzylisoquinoline alkaloids
AssigneeAntheia, Inc.
InventorsChristina D. Smolke, Catherine Thodey, Isis Trenchard
Life of this patent
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Abstract
A method of demethylizing an opioid to a nor-opioid is provided. The method comprises contacting an opioid with at least one enzyme. Contacting the opioid with the at least one enzyme converts the opioid to a nor-opioid. A method of converting a nor-opioid to a nal-opioid is provided. The method comprises contacting a nor-opioid with at least one enzyme. Contacting the nor-opioid with the at least one enzyme converts the nor-opioid to a nal-opioid.
Claims7
A method of demethylating an opioid to a nor-opioid, comprising:
- contacting a first opioid with at least one enzyme within an engineered non-plant cell, wherein contacting the first opioid with the at least one enzyme converts the first opioid to a second opioid through loss of an O-linked methyl group;
- and
- contacting the second opioid with at least one enzyme within the engineered non-plant cell, wherein contacting the opioid with the at least one enzyme converts the second opioid to a nor-opioid through loss of an N-linked methyl group.
Dependencies are inferred from the claim text.