Chromatographic cassette
AssigneeSpf Technologies LLC
InventorGaston de los Reyes
Life of this patent
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Abstract
A chromatographic cassette includes a cassette including a chamber, chromatographic media disposed within the cassette chamber, a distribution network fluidly coupled to the chromatographic media and an inlet port and an outlet port coupled to the distribution network. A hyper-productive chromatography technique includes providing a scalable and stackable chromatographic cassette, loading a sample to be processed, operating the scalable chromatographic cassette having an adsorptive chromatographic bed having a volume greater than 0.5 liter by establishing a flow at a linear velocity greater than 500 cm/hr with a residence time of the loading step of less than one minute.
Claims21
An adsorptive device comprising:
- at least one adsorptive block comprising planarly cohesive, substantially isotropic adsorptive media, the adsorptive block having:
- a first end;
- a second end disposed opposite the first end;
- a first substantially planar surface disposed between the first end and the second end;
- a second substantially planar surface substantially parallel to the first substantially planar surface, the planarly cohesive, substantially isotropic adsorptive media disposed in between the first substantially planar surface and the second substantially planar surface;
- at least one sidewall disposed substantially perpendicular to the first and second planar surfaces;
- a first plurality of distribution passageways disposed adjacent the at least one adsorptive block, adjacent the first end and substantially perpendicular to the first and second planar surfaces;
- a second plurality of distribution passageways disposed adjacent the at least one adsorptive block, adjacent the second end and substantially perpendicular to the first and second planar surfaces;
- a first planar distributor disposed adjacent the first substantially planar surface in fluid communication with the first plurality of distribution passageways;
- a second planar distributor disposed adjacent the second substantially planar surface in fluid communication with the second plurality of distribution passageways;
- a peripheral seal encapsulating the at least one sidewall;
- and
- wherein the first and second planar distributors induce a substantially uniform perpendicular fluid flow through the planarly cohesive, substantially isotropic adsorptive media within the at least one adsorptive block from the first planar surface to the second planar surface.
Dependencies are inferred from the claim text.