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US 11,389,545 B2Granted
Bioactive nanoparticles and methods for making same
OwnerSean Matthew Andersoninventor
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Abstract
The present invention provides a composition of nanoparticles comprising a biological mimetic base component that forms the structure of the nanoparticle. By interacting with the functional groups of the base component, the half-life of a bioactive molecule is extended.
Claims15
A nanoparticle composition, comprising:
- a plurality of nanoparticles, each nanoparticle comprising a base component that comprises a polymer from a non-animal source that mimics a macromolecule of an animal extracellular matrix, wherein a plurality of the polymer molecules are covalently bonded through an internal crosslinking subcomponent to form the structure of each nanoparticle, wherein the internal crosslinking subcomponent has a linkage type selected from the group consisting of amine-acrylamide, amine-vinyl, amine-acrylate, vinyl-hydrazide, and acrylate-hydrazide and wherein the internal crosslinking subcomponent has a molecular weight of less than 10 kDa;
- and an external binding subcomponent covalently bonded to the base component and configured to bond with and stabilize a bioactive molecule at a dissociation constant of less than 10 micromolar, wherein the bioactive molecule is an animal growth factors.
Dependencies are inferred from the claim text.