Flavivirus and alpha virus virus-like particles (VLPS)
AssigneeTechnoVax, Inc.
InventorsJose M. Galarza, Helene Boigard, George Martin
Life of this patent
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Abstract
Flavivirus virus-like particles (VLPs) are provided that display on their surfaces antigenic flavivirus proteins. The VLPs include at least one flavivirus structural protein and at least one non-structural flavivirus protein. A DNA construct that includes sequences encoding flavivirus viral proteins used to assemble the flavivirus VLP is also provided. A method of producing flavivirus VLPs by introducing one or more the DNA constructs into a host cell is also provided. An immunogenic composition that includes the flavivirus VLP is also provided.
Claims18
A virus-like particle (VLP) comprising at least one flavivirus structural protein;
- and at least one non-structural flavivirus protein, wherein the at least one non-structural flavivirus protein comprises a truncated NS3 protein co-expressed with a truncated NS2B protein.
Dependencies are inferred from the claim text.