Myeloperoxidase compositions and methods for inhibition of lipopolysaccharides and lipid A
AssigneeExOxEmis, Inc.
InventorRobert C. Allen
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Abstract
Compositions comprising a combination of myeloperoxidase and a peroxide-producing oxidase and methods of using the compositions to inactivate gram negative bacterial lipopolysaccharides and lipid A endotoxin are provided.
Claims6
A method of inhibiting activity of a lipopolysaccharide endotoxin present at a site in a human or animal subject infected with gram negative bacteria, the method consisting of administering a composition to the site where the lipopolysaccharide endotoxin is present, the composition consisting of myeloperoxidase and a pharmaceutically acceptable carrier, wherein the myeloperoxidase directly contacts, binds to, and inhibits the activity of the lipopolysaccharide endotoxin.
Dependencies are inferred from the claim text.