A method of calculating a brain volume of a brain of a patient, the method comprising:
- obtaining a first plurality of magnetic resonance images (MRIs) of the brain at a first time point, wherein the first plurality of MRIs includes at least two first time point MRIs;
- obtaining a second plurality of MRIs of the brain at a second time point, wherein the second plurality of MRIs includes at least two second time point MRIs;
- calculating, with a first algorithm, a first brain volume value at the first time point based on the at least two first time point MRIs, and a second brain volume value at the second time point based on the at least two second time point MRIs;
- calculating, with a second algorithm, a third brain volume value at the first time point based on the at least two first time point MRIs, and a fourth brain volume value at the second time point based on the at least two second time point MRIs, wherein the second algorithm is different from the first algorithm;
- applying at least one of (a) a first algorithm mathematical weight to at least one of the first brain volume value and the second brain volume value, the first algorithm mathematical weight being associated with the first algorithm, to obtain a first mathematically-weighted value, and (b) a second algorithm mathematical weight to at least one of the third brain volume value and the fourth brain volume value, the second algorithm mathematical weight being associated with the second algorithm, to obtain a second mathematically-weighted value, wherein the first mathematically-weighted value is a product of the first algorithm mathematical weight and the at least one of the first brain volume value and the second brain volume value, and the second mathematically-weighted value is a product of the second algorithm mathematical weight and the at least one of the third brain volume value and the fourth brain volume value,
- wherein each of the first algorithm mathematical weight and the second algorithm mathematical weight is calculated based on at least one of:
- an image quality score, a reliability index of the corresponding algorithm, historical data of the corresponding algorithm, a measurement error of the corresponding algorithm, a synchronicity of the corresponding algorithm, a performance of the corresponding algorithm, and a degree of similarity with one or more other brain volume values;
- and
- determining an overall first time point brain volume value at the first time point by averaging the first brain volume value and the second mathematically-weighted value or by averaging the first mathematically-weighted value and the third brain volume;
- and
- determining an overall second time point brain volume value at the second time point by averaging the second brain volume value and the second mathematically-weighted value or by averaging the first mathematically-weighted value and the fourth brain volume value.