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US 11,384,341 B2Granted
Omega-hydroxylase-related fusion polypeptide variants with improved properties
AssigneeGenomatica, Inc.
InventorsAndreas Schirmer, Baolong Zhu, Emanuela Popova
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Abstract
The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.
Claims11
A cytochrome P450 CYP153A reductase (CYP153A-reductase) hybrid fusion polypeptide variant comprising at least 90% sequence identity to the amino acid sequence of SEQ ID NO:
- 38, wherein said CYP153A-reductase hybrid fusion polypeptide variant comprises a mutation at amino acid position 159.
Dependencies are inferred from the claim text.