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US 11,384,135 B2Granted
Recombinant yeast strains
AssigneeModern Meadow, Inc.
InventorsLixin Dai, Poonam Srivastava
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Abstract
This invention relates to genetically engineered strains of yeast and methods, for producing recombinant protein (e.g., collagen). Recombinant protein of the present invention is used to produce biofabricated leather or a material having leather-like properties containing recombinant or engineered collagen. The yeast strains are engineered to produce ascorbate and/or increased production of α ketoglutarate.
Claims8
A recombinant yeast cell, comprising an exogenous polynucleotide that encodes GDP-L-Gal phosphorylase,
- wherein the recombinant yeast cell is Pichia pastoris,
- wherein the recombinant yeast cell further comprises a polynucleotide encoding bovine collagen, and
- wherein the exogenous polynucleotide is SEQ ID NO:
- 18 and the polynucleotide encoding bovine collagen is SEQ ID NO:
- 11.
2 more elements
Dependencies are inferred from the claim text.