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US 11,384,051 B2Granted
Ionizable compounds and compositions and uses thereof
AssigneeNitto Denko Corporation
InventorsRoger Adami, Hao Bai, John Gaudette, Bharat Majeti, Seiji Nukui, Kwok Yin Tsang, Hai Wang, Haiqing Yin, Wenbin Ying
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Abstract
This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.
Claims14
A compound comprising the structure shown in Formula I:
- wherein R1 and R2 are
- R1=CH2(CH2)nOC(═O)R4
- R2=CH2(CH2)mOC(═O)R5
- wherein n and m are each independently from 1 to 2;
- R4 and R5 are independently for each occurrence a C(12-20) alkyl group, or a C(12-20) alkenyl group;
- R3 is selected from
- wherein
- each R6 is independently selected from alkyl, hydroxyl, hydroxyalkyl, alkoxy, alkoxyalkoxy, and aminoalkyl;
- each R8 is independently selected from alkyl, and aminoalkyl, and any two R8 may form a ring;
- each R10 is independently selected from alkyl, hydroxyl, hydroxyalkyl, alkoxy, alkoxyalkoxy, and aminoalkyl;
- q is from zero to four;
- p is from 1 to 4,
- wherein the number of double bonds of R4 and R5 is 3 or more when R8 is methyl.
10 more elements
Dependencies are inferred from the claim text.