Aromatic vinyl or aromatic ethyl derivative, preparation method therefor, intermediate, pharmaceutical composition, and application

An aromatic vinyl or aromatic ethyl derivative represented by formula (II), a pharmaceutically acceptable salt or a prodrug thereof:

• wherein,
• is a single bond or a double bond;
• each of R1 is identical or different, and is independently deuterium, halogen, substituted or unsubstituted hydroxyl, substituted or unsubstituted amino, substituted or unsubstituted alkyl, or substituted or unsubstituted alkoxy;
• or two adjacent R1 together with the two carbon atoms to which they are attached form a 5- to 7-membered carbocyclic ring or heterocarbocyclic ring;
• in the heterocarbocyclic ring, the heteroatom(s) is(are) oxygen and/or nitrogen, and the number of the heteroatom(s) is 1 to 4;
• wherein, the carbon labelled by * is an S-configuration chiral carbon, an R-configuration chiral carbon or an achiral carbon;
• R2 is substituted or unsubstituted alkyl or halogen;
• each of R3 is identical or different, and is independently deuterium, halogen, substituted or unsubstituted alkylthio, substituted or unsubstituted hydroxyl, substituted or unsubstituted amino, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy,
• wherein R1a is C1-C4 alkyl;
• the substituent(s) in the substituted alkyl in each of R1, R2 and each of R3, the substituent(s) in the substituted alkoxy in each of R1 and each of R3, and the substituent(s) in the substituted alkylthio in each of R3 are one or more selected from halogen, C1-4 alkyl, hydroxyl,
• C1-4 alkoxy, C1-4 carboxyl, C1-4 ester group and C1-4 amide group;
• when there are more substituents than one, then the substituents are identical or different;
• Ra and Rb are independently hydrogen, or, substituted or unsubstituted alkyl;
• in Ra or Rb, the substituent(s) in the substituted alkyl is(are) one or more selected from halogen, C1-C4 alkyl, hydroxyl,
• C1-C4 alkoxy, C1-C4 carboxyl, C1-C4 ester group and C1-C4 amide group;
• Ra1 and Rb1 are independently hydrogen or C1-C4 alkyl;
• in each of R1 or R3, the substituent(s) in the substituted hydroxyl or the substituted amino is(are) one or more selected from C1-4 alkyl, C1-4 alkoxy, C1-4 carboxyl, C1-4 ester group and C1-4 amide group;
• m1 is 0, 1 or 2;
• n is 0, 1, 2 or 3;
• when is a double bond and m1 is 1, then R1 is located on ortho positions of the phenyl;
• when is a double bond and m1 is 2, then two of R1 are adjacent, and the two adjacent R1 together with the two carbon atoms to which they are attached form a 5- to 7-membered heterocarbocyclic ring.