Adjuvant composition and use thereof
AssigneeRiken
InventorsShinichiro Fujii, Kanako Shimizu
Life of this patent
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Abstract
The present invention provides an adjuvant that can cause immune activation or particularly T cell immune activation. The present invention provides an adjuvant that can cause particularly antigen-specific immune activation or particularly T cell immune activation.
Claims9
A method of activating antigen-specific immunity against an immunogenic substance in a subject, comprising administering to the subject an effective amount of an adjuvant composition comprising human Granzyme A and the immunogenic substance.
A method of activating antigen-specific immunity against an immunogenic substance in a subject, comprising administering to the subject an effective amount of an adjuvant composition comprising an immunogenic substance and Granzyme A, wherein the Granzyme A is Granzyme A in which an amino acid corresponding to an amino acid at position 184 in the amino acid sequence set forth in SEQ ID NO:
- 3 is changed by substitution of serine with another amino acid, and wherein serine protease activity of the Granzyme A is lower than that of a human Granzyme A having an amino acid sequence set forth in SEQ ID NO:
- 3.
A method of activating antigen-specific T cell immunity or B cell immunity against an immunogenic substance in a subject, comprising administering to the subject an effective amount as an adjuvant of human Granzyme A, and the immunogenic substance.
Dependencies are inferred from the claim text.