Multi-functional peptides and use thereof

A peptide having antibacterial and immunomodulatory activity which consists of 7 to 12 amino acids comprising an amino acid sequence selected from the group consisting of:

• i) BOBW-NleOm (SEQ ID NO:
• 18), BOBWZOm (SEQ ID NO:
• 20), and BOBWBOMVm (SEQ ID NO:
• 21);
• and
• ii) ZRWWX1X2m (SEQ ID NO:
• 22), RRWWX1X2m (SEQ ID NO:
• 23), and ZRWWRX2WWRWm (SEQ ID NO:
• 24);
• wherein:
• B is a basic amino acid independently selected from the group consisting of lysine (K) and arginine (R);
• O is an aromatic amino acid independently selected from the group consisting of phenylalanine (F), tyrosine (Y), and tryptophan (W);
• X1 is independently selected from the group consisting of arginine (R), norleucine (Nle), and 2-naphthyl-L-alanine (Z);
• X2 is independently selected from the group consisting of norleucine (Nle), tryptophan (W), and valine (V);
• m is D-type methionine, and
• Z is 2-naphthyl-L-alanine.