Compounds reducing malodour perception and the use thereof

An OR7D4 antagonist, wherein the antagonist comprising a compound of formula (I) or a stereoisomer thereof,

• wherein the compound or stereoisomer thereof is an antagonist of the OR7D4 receptor, and wherein
• X is selected from the group consisting of —CN, —C(═O)OR8, —C(═O)—C1-6alkyl, —C(═O)—NR9R10, —CH2—OH, —CH2—CH2—OH, —C(═O)H, and C1-6alkoxyC1-6alkyl;
• R1 is hydrogen or C1-6 alkyl;
• R2 is a group selected from C5-6 alkyl, C5-6 alkenyl, 3-tert-butyl-1-methylpropyl, or C1alkyl substituted with a C5cycloalkyl;
• R3 is selected from the group consisting of hydrogen, halo, C1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, and cyano;
• R4 is selected from the group consisting of hydrogen, halo, C1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, and cyano;
• R5 is selected from the group consisting of hydrogen, halo, C1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, and cyano;
• R6 is selected from the group consisting of hydrogen, halo, C1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, and cyano;
• R7 is selected from the group consisting of hydrogen, halo, C1-6alkyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, and cyano;
• R8 is hydrogen or C1-6alkyl;
• R9 is hydrogen or C1-6alkyl;
• R10 is hydrogen or C1-6alkyl;
• with the following provisos:
• when X is —C(═O)—NR9R10 then R1 is —CH3;
• when X is —C(═O)H or —C(═O)OR8, then R4 is not C1-6alkoxy;
• and the compound of formula (I) is none of:
• methyl (2E,4E)-4-(4-fluorobenzylidene)-2-nonenoate;
• (2E,4Z)-4-benzylidene-2-methyldec-2-en-1-ol,
• methyl (2E,4E)-4[(4-methoxyphenyl)methylene]non-2-enoate;
• and
• (2E,4E)-4-benzylidenedec-2-enenitrile.