System and method for surgical guidance and intra-operative pathology through endo-microscopic tissue differentiation

An apparatus for image registration, comprising:

• means for extracting personalized biomechanical parameters from a first region of tissue of a patient in an inverse problem of the biomechanical model using pre-operative imaging data and intra-operative imaging data, the first region of the tissue of the patient including a first portion of an outer layer of the tissue of the patient and a first portion of an inner layer of the tissue of the patient;
• means for identifying correspondences between a second portion of the outer layer of the tissue of the patient of a second region of the tissue in the pre-operative imaging data and the second portion of the outer layer of the tissue of the patient of the second region of the tissue in the intra-operative imaging data;
• and
• means for determining a deformation of a second portion of the inner layer of the tissue of the patient of the second region of the tissue in the pre-operative imaging data based on the identified correspondences by applying the biomechanical model with the personalized biomechanical parameters.

A non-transitory computer readable medium storing computer program instructions for image registration, the computer program instructions when executed by a processor cause the processor to perform operations comprising:

• extracting personalized biomechanical parameters from a first region of tissue of a patient in an inverse problem of the biomechanical model using pre-operative imaging data and intra-operative imaging data, the first region of the tissue of the patient including a first portion of an outer layer of the tissue and a first portion of an inner layer of the tissue;
• identifying correspondences between a second portion of the outer layer of the tissue of a second region of the tissue in the pre-operative imaging data and the intra-operative imaging data;
• and
• determining a deformation of a second portion of the inner layer of the tissue of the second region of the tissue in the pre-operative imaging data based on the identified correspondences by applying the biomechanical model with the personalized biomechanical parameters.

A method for image registration, comprising:

• extracting personalized biomechanical parameters from a first region of tissue of a patient in an inverse problem of the biomechanical model using pre-operative imaging data and intra-operative imaging data;
• identifying correspondences between an outer layer of a second region of the tissue in the pre-operative imaging data and the outer layer of the second region of the tissue in the intra-operative imaging data;
• and
• determining a deformation of an inner layer of the second region of the tissue in the pre-operative imaging data based on the identified correspondences by applying the biomechanical model with the personalized biomechanical parameters;
• wherein the first region of the tissue is a region of higher imaging accuracy in an inner layer of the tissue in the intra-operative imaging data, and
• wherein the second region of the tissue is a region of lower imaging accuracy in the inner layer of the tissue in the intra-operative imaging data.