Method for predicting the risk of deep vein thrombosis and pulmonary embolism associated with hormonal preparations and hormone levels
AssigneeGene Gender S.R.L.
InventorsGoranka Tanackovic Abbas-Terki, Joëlle Michaud Schutz, Thierry Daniel Pache
Life of this patent
Estimating the term…
Abstract
Specific single nucleotide polymorphisms (SNPs) in the human genome, and their association with deep vein thrombosis (DVT) and related pathologies, such as pulmonary embolism (PE), in relation with hormonal preparations (i.e. combined contraceptives, hormone replacement therapeutics) and hormone levels (i.e. during pregnancy and post-partum).
Claims6
A treatment method for a woman subject undergoing a change in hormone levels having a risk of developing a blood clotting disease, the method comprising:
- determining, in a sample from said woman subject,
- genotyping data including the single nucleotide polymorphisms of rs1799853 (SEQ ID NO:1), rs4379368 (SEQ ID NO:2), rs6025 (SEQ ID NO:3), rs1799963 (SEQ ID NO:4), rs8176719 (SEQ ID NO:5), rs8176750 (SEQ ID NO:6), rs9574 (SEQ ID NO:7), rs2289252 (SEQ ID NO:8), and rs710446 (SEQ ID NO:9);
- computing a risk score of the woman subject for developing a blood clotting disease by combining (i) the genotyping data and (ii) clinical risk factors of the woman subject selected from the group consisting of smoking status, body mass index (BMI), age, familial history of blood clotting diseases, and change in hormone levels;
- and
- administering an effective amount of a compound adapted to the prevention of a blood clotting disease, to the woman subject on the basis of the computed risk score to decrease the risk of the woman subject for developing a blood clotting disease.
A treatment method for a woman subject undergoing a change in hormone levels, said method comprising:
- selecting woman subject-specific input features comprising:
- (i) the genotype of single nucleotide polymorphisms of rs1799853 (SEQ ID NO:1), rs4379368 (SEQ ID NO:2), rs6025 (SEQ ID NO:3), rs1799963 (SEQ ID NO:4), rs8176719 (SEQ ID NO:5), rs8176750 (SEQ ID NO:6), rs9574 (SEQ ID NO:7), rs2289252 (SEQ ID NO:8), and rs710446 (SEQ ID NO:9);
- and
- (ii) the clinical risk factors of the woman subject comprising smoking status, BMI, age, familial history of blood clotting diseases and change in hormone levels of said woman subject;
- computing an estimation value by applying a decision support algorithm as a function of numerical values derived from the selected input features;
- and
- administering an effective amount of a compound adapted to the prevention of a blood clotting disease, to the woman subject on the basis of the computed estimation value to decrease the risk of the woman subject for developing a blood clotting disease.
Dependencies are inferred from the claim text.