Method of detecting and/or identifying adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby
AssigneeThe Trustees of the University of Pennsylvania
InventorsGuangping Gao, James M. Wilson, Mauricio R. Alvira
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Abstract
Adeno-associated virus rh.20 sequences, vectors containing same, and methods of use are provided.
Claims16
A cultured host cell containing a recombinant nucleic acid molecule encoding an AAV vp1 capsid protein having a sequence comprising amino acids 1 to 738 of SEQ ID NO:
- 85 (AAVrh.20), wherein the recombinant nucleic acid molecule further comprises a heterologous non-AAV sequence.
A cultured host cell containing a recombinant nucleic acid molecule encoding an AAV vp2 capsid protein having a sequence comprising amino acids 138 to 738 of SEQ ID NO:
- 85 (AAVrh.20), wherein the recombinant nucleic acid molecule further comprises a heterologous non-AAV sequence.
A cultured host cell containing a recombinant nucleic acid molecule encoding an AAV vp3 capsid protein having a sequence comprising amino acids 204 to 738 of SEQ ID NO:
- 85 (AAVrh.20), wherein the recombinant nucleic acid molecule further comprises a heterologous non-AAV sequence.
A cultured host cell containing a recombinant nucleic acid molecule comprising (a) nucleotides 844 to 3057 of SEQ ID NO:
- 27, (b) nucleotides 1255 to 3057 of SEQ ID NO:
- 27, or (c) nucleotides 1453 to 3057 of SEQ ID NO:
- 27, wherein the recombinant nucleic acid molecule further comprises a heterologous non-AAV sequence.
Dependencies are inferred from the claim text.