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US 11,377,651 B2Granted
Cell therapy processes utilizing acoustophoresis
AssigneeFloDesign Sonics, Inc.
InventorsBart Lipkens, Rui Tostoes, Brian Dutra, Rudolf Gilmanshin, Jason Dionne, Walter M. Presz, Jr., Benjamin Ross-Johnsrud, Goutam Ghoshal, Kedar Chitale
Life of this patent
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Abstract
A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.
Claims10
A system for producing a therapeutic by implementing a series of processes, the system comprising:
- a user interface for accepting a user input for process selection;
- a cell processing device for performing a process on a cell suspension to obtain a processed cell suspension;
- an acoustic device fluidly connected to the cell processing device with a closed connection and being configured to selectively implement a concentrate process, a washing process or an affinity selection process on the cell suspension or on the processed cell suspension, wherein the acoustic device includes an ultrasonic transducer configured to generate an acoustic wave to retain cellular material or a structure to which the cellular material is bound;
- a chamber in the acoustic device for receiving the cellular material or a structure to which the cellular material is bound, the ultrasonic transducer being coupled to the chamber;
- at least a portion of the chamber near the ultrasonic transducer being vertically oriented;
- a valve coupled to the chamber for controlling fluid flow into or out of the chamber;
- and
- a controller coupled to the user interface, the valve and the ultrasonic transducer and configured to control the valve and the ultrasonic transducer to implement a selected concentrate process, washing process or affinity selection process based on the user input.
5 more elements
A cell therapy production system, comprising:
- a user configured to accept a user input for process selection;
- a number of fluidly interconnected devices that form a closed system, at least one of the devices being a cell processing device for performing a process on a cell suspension to obtain a processed cell suspension, and at least another one of the devices being an acoustic device configured to retain cells or structures for supporting cells in the cell suspension or in the processed cell suspension;
- the acoustic device including an ultrasonic transducer coupled to a vertically oriented chamber through which the cell suspension or the processed cell suspension is flowed;
- and
- a controller coupled to the user interface and the acoustic device and configured to control the acoustic device to implement a concentrate process, a washing process or an affinity selection process based on the user input.
2 more elements
Dependencies are inferred from the claim text.