Engineered skin equivalent, method of manufacture thereof and products derived therefrom

A method of forming a tanned synthetic leather, wherein said method comprises:

• 1) forming an artificial dermal layer comprising a fibroblast on a scaffold, wherein said scaffold comprises a bioabsorbable synthetic polymer, a cellulose, a cotton, an acetate, an acrylic, a fiber, a linen, a nylon, a rayon, a velvet, a modacrylic, an olefin polyester, a saran, a vinyon, a wool, a jute, a hemp, a bamboo, a flax, or any combination thereof;
• 2) removing at least a portion of a cell layer from said artificial dermal layer;
• and
• 3) tanning at least a portion of said artificial dermal layer to generate said tanned synthetic leather.